Peroxide is a key mediator of Bcl-2 down-regulation and apoptosis induction by cisplatin in human lung cancer cells.

@article{Wang2008PeroxideIA,
  title={Peroxide is a key mediator of Bcl-2 down-regulation and apoptosis induction by cisplatin in human lung cancer cells.},
  author={Liying Wang and Pithi Chanvorachote and David G{\'o}mez Toledo and Christian Stehlik and Robert R. Mercer and Vincent Castranova and Yon Rojanasakul},
  journal={Molecular pharmacology},
  year={2008},
  volume={73 1},
  pages={119-27}
}
Susceptibility to apoptosis is an essential prerequisite for successful eradication of tumor cells by chemotherapy. Consequently, resistance to apoptosis has been established as one of the mechanisms responsible for the failure of therapeutic approaches in many types of cancers. In the present study, we investigated the susceptibility of human lung cancer H460 cells to apoptotic cell death induced by cisplatin and determined its regulatory mechanisms. Treatment of the cells with cisplatin… CONTINUE READING

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