Peroxide formation in polysorbate 80 and protein stability.

  title={Peroxide formation in polysorbate 80 and protein stability.},
  author={Emily Ha and Wei Wang and Yong Wang},
  journal={Journal of pharmaceutical sciences},
  volume={91 10},
Nonionic surfactants are widely used in the development of protein pharmaceuticals. However, the low level of residual peroxides in surfactants can potentially affect the stability of oxidation-sensitive proteins. In this report, we examined the peroxide formation in polysorbate 80 under a variety of storage conditions and tested the potential of peroxides in polysorbate 80 to oxidize a model protein, IL-2 mutein. For the first time, we demonstrated that peroxides can be easily generated in… CONTINUE READING

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