Peroxidative stress and antioxidant enzymes in children with beta-thalassemia major.

  title={Peroxidative stress and antioxidant enzymes in children with beta-thalassemia major.},
  author={Rahul Naithani and Jagdish Chandra and J. B. Bhattacharjee and Priyanka Verma and Shashi Narayan},
  journal={Pediatric blood & cancer},
  volume={46 7},
OBJECTIVE Regular blood transfusions and secondary iron overload make thalassemic erythrocytes prone to peroxidative injury. Although some reports suggest endogenous free radical damage in thalassemia, there remains discrepancy in the status of antioxidant enzymes. The aim of this study was to evaluate the extent of lipid peroxidation and status of antioxidant enzyme in children with beta-thalassemia. METHODS Fifty transfusion-dependent beta-thalassemics were subjected to analysis of… CONTINUE READING
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