Peroxidation of synaptosomes alters the dopamine uptake complex but spares the exocytotic release of dopamine.

@article{Ramassamy1995PeroxidationOS,
  title={Peroxidation of synaptosomes alters the dopamine uptake complex but spares the exocytotic release of dopamine.},
  author={Ch Ramassamy and F Girbe and Yves Christen and Jean Costentin},
  journal={Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration},
  year={1995},
  volume={4 2},
  pages={155-60}
}
Synaptosomes, prepared from the striata of mice, and incubated for 1 h in a Krebs-Ringer medium with the peroxidative combination of ascorbic acid (0.1 mM)/Fe2+ (1 microM), lose their ability to take up [3H] dopamine. This effect is associated with a decrease in binding of the dopamine uptake inhibitor [3H] GBR 12783. The free radical scavenger trolox C (0.1 mM) and the Ginkgo biloba extract EGb 761 (10 micrograms/ml) prevent both effects. Although submitted to these peroxidative conditions… CONTINUE READING