Peroxidation of n-3 Polyunsaturated Fatty Acids Inhibits the Induction of iNOS Gene Expression in Proinflammatory Cytokine-Stimulated Hepatocytes

@inproceedings{Araki2011PeroxidationON,
  title={Peroxidation of n-3 Polyunsaturated Fatty Acids Inhibits the Induction of iNOS Gene Expression in Proinflammatory Cytokine-Stimulated Hepatocytes},
  author={Y. Araki and Miho Matsumiya and Takashi Matsuura and Masaharu Oishi and Masaki Kaibori and Tadayoshi Okumura and Mikio Nishizawa and Hideho Takada and A. Hon Kwon},
  booktitle={Journal of nutrition and metabolism},
  year={2011}
}
Eicosapentaenoic acid and docosahexaenoic acid (EPA/DHA), n-3 polyunsaturated fatty acids (PUFAs), have a variety of biological activities including anti-inflammatory and anticancer effects. We hypothesized that their peroxidized products contributed in part to anti-inflammatory effects. In the liver, the production of nitric oxide (NO) by inducible nitric… CONTINUE READING