Peroxidasin forms sulfilimine chemical bonds using hypohalous acids in tissue genesis.

@article{Bhave2012PeroxidasinFS,
  title={Peroxidasin forms sulfilimine chemical bonds using hypohalous acids in tissue genesis.},
  author={Gautam Bhave and Christopher F. Cummings and Roberto M Vanacore and Chino Kumagai-Cresse and Isi A. Ero-Tolliver and Mohamed Rafi and Jeong-Suk Kang and Vadim Pedchenko and Liselotte I. Fessler and John H. Fessler and Billy G Hudson},
  journal={Nature chemical biology},
  year={2012},
  volume={8 9},
  pages={784-90}
}
Collagen IV comprises the predominant protein network of basement membranes, a specialized extracellular matrix, which underlie epithelia and endothelia. These networks assemble through oligomerization and covalent crosslinking to endow mechanical strength and shape cell behavior through interactions with cell-surface receptors. A recently discovered sulfilimine (S=N) bond between a methionine sulfur and hydroxylysine nitrogen reinforces the collagen IV network. We demonstrate that peroxidasin… CONTINUE READING