Peroxidase Antimicrobial System of Human Saliva: Requirements for Accumulation of Hypothiocyanite

@article{Thomas1981PeroxidaseAS,
  title={Peroxidase Antimicrobial System of Human Saliva: Requirements for Accumulation of Hypothiocyanite},
  author={E. Thomas and K. Bates and M. Jefferson},
  journal={Journal of Dental Research},
  year={1981},
  volume={60},
  pages={785 - 796}
}
  • E. Thomas, K. Bates, M. Jefferson
  • Published 1981
  • Chemistry, Medicine
  • Journal of Dental Research
  • Human saliva was fractionated to determine the components required for production and accumulation of the antimicrobial oxidizing agent, hypothiocyanite ion (OSCN-). The required components were: 1) peroxidase activity and thiocyanate ion (SCN -), 2) the saliva sediment, which produced hydrogen peroxide (H 2O2) in the presence of oxygen and a divalent cation, and 3) heatstable factors of the saliva supernatant. The supernatant factors were separated into high- and low-mol wt fractions. The high… CONTINUE READING
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