Permissive role of glucocorticoids on interleukin-1 activation of the hypothalamic serotonergic system.

@article{Gemma1994PermissiveRO,
  title={Permissive role of glucocorticoids on interleukin-1 activation of the hypothalamic serotonergic system.},
  author={Carolina Gemma and Ada De Luigi and Maria-Grazia De Simoni},
  journal={Brain research},
  year={1994},
  volume={651 1-2},
  pages={169-73}
}
The present study analyses the effect of IL-1 beta (10 ng i.c.v.) on the hypothalamic serotonergic system and the modulatory role of glucocorticoids. Changes in the serotonin metabolite 5-hydroxyindolacetic acid (5-HIAA) were recorded in freely moving rats by in vivo voltammetry using chronically implanted carbon fiber electrodes (8 microns) in the medial preoptic area. IL-1 beta induced a dual increase in 5HIAA levels: a rapid, short-term rise was followed by a lasting increase possibly due to… CONTINUE READING