Permissive environment in postnatal wounds induced by adenoviral-mediated overexpression of the anti-inflammatory cytokine interleukin-10 prevents scar formation.

@article{Gordon2008PermissiveEI,
  title={Permissive environment in postnatal wounds induced by adenoviral-mediated overexpression of the anti-inflammatory cytokine interleukin-10 prevents scar formation.},
  author={Ashley D Gordon and Elliott D Kozin and Sundeep G. Keswani and Sachin S Vaikunth and Anna B. Katz and Philip W. Zoltick and Michele Favata and Antoneta P Radu and Louis J Soslowsky and Meenhard Herlyn and Timothy M. Crombleholme},
  journal={Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society},
  year={2008},
  volume={16 1},
  pages={70-9}
}
Wound healing in the mid-gestation fetus is scarless with minimal inflammation and a unique extracellular matrix. We have previously documented the relative lack of inflammatory cytokines in this environment. We demonstrate that interleukin (IL)-10 is highly expressed in mid-gestation human fetal skin but is absent in postnatal human skin. We hypothesize that overexpression of IL-10 in postnatal skin may replicate a permissive environment for scarless healing. To study the mechanism underlying… CONTINUE READING

From This Paper

Topics from this paper.
28 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Similar Papers

Loading similar papers…