Permissive corridor and diffusible gradients direct medial ganglionic eminence cell migration to the neocortex.

@article{Wichterle2003PermissiveCA,
  title={Permissive corridor and diffusible gradients direct medial ganglionic eminence cell migration to the neocortex.},
  author={Hynek Wichterle and Manuel {\'A}lvarez-Dolado and Lynda Erskine and Arturo Alvarez-Buylla},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 2},
  pages={727-32}
}
Young neurons born in the medial ganglionic eminence (MGE) migrate a long distance dorsally, giving rise to several types of interneurons in neocortex. The mechanisms that facilitate selective dorsal dispersion of MGE cells while restricting their movement ventrally into neighboring regions are not known. Using microtransplantation into fetal brain slices and onto dissociated substrate cells on floating filters (spot assay), we demonstrate that ventral forebrain regions neighboring the MGE are… CONTINUE READING

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