Permeation studies and histological examination of sheep nasal mucosa following administration of different nasal formulations with or without absorption enhancers.

@article{Karasulu2008PermeationSA,
  title={Permeation studies and histological examination of sheep nasal mucosa following administration of different nasal formulations with or without absorption enhancers.},
  author={Ercument Karasulu and Altuğ Yavaşoğlu and Z Evrensanal and Yiğit Uyanikgil and Hatice Yeşim Karasulu},
  journal={Drug delivery},
  year={2008},
  volume={15 4},
  pages={
          219-25
        }
}
This study was designed to investigate the possible histological effects of different intranasal (IN) formulations of indomethacin (IND) on nasal mucosa in sheep. For this purpose, oil-in-water (O/W) emulsion (E) and solution (S) formulations including 3 mg/mL of IND were prepared. Penetration enhancers such as polyvinylpyrolidone (PVP), citric acid (CA) and sodium taurocholate (NaT) were added to emulsion (1%) at the final step into the formulations. First, the effect of penetration enhancers… Expand
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