Permeation of aromatic carboxylic acids across lipid bilayers: the pH-partition hypothesis revisited.

@article{Thomae2005PermeationOA,
  title={Permeation of aromatic carboxylic acids across lipid bilayers: the pH-partition hypothesis revisited.},
  author={Anita V. Thomae and Heidi Wunderli-Allenspach and Stefanie D. Kr{\"a}mer},
  journal={Biophysical journal},
  year={2005},
  volume={89 3},
  pages={1802-11}
}
According to the pH-partition hypothesis the charged species of organic compounds do not contribute to lipid bilayer permeation as they generally show negligible partitioning into n-octanol. With this assumption, membrane permeation is related to the molar fraction of the neutral species at a particular pH. A recently developed permeation assay permits us to directly determine pH-dependent permeation of aromatic carboxylic acids. Tb(3+)-loaded liposomes are incubated with aromatic carboxylic… CONTINUE READING