Permeation and Gating in CaV3.1 (α1G) T-type Calcium Channels Effects of Ca2+, Ba2+, Mg2+, and Na+

@article{Khan2008PermeationAG,
  title={Permeation and Gating in CaV3.1 (α1G) T-type Calcium Channels Effects of Ca2+, Ba2+, Mg2+, and Na+},
  author={Nilofar Khan and I. Patrick Gray and Carlos A. Obejero-Paz and Stephen W. Jones},
  journal={The Journal of General Physiology},
  year={2008},
  volume={132},
  pages={223 - 238}
}
We examined the concentration dependence of currents through Ca(V)3.1 T-type calcium channels, varying Ca(2+) and Ba(2+) over a wide concentration range (100 nM to 110 mM) while recording whole-cell currents over a wide voltage range from channels stably expressed in HEK 293 cells. To isolate effects on permeation, instantaneous current-voltage relationships (IIV) were obtained following strong, brief depolarizations to activate channels with minimal inactivation. Reversal potentials were… CONTINUE READING
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