Permeating protons contribute to tachyphylaxis of the acid-sensing ion channel (ASIC) 1a.

@article{Chen2007PermeatingPC,
  title={Permeating protons contribute to tachyphylaxis of the acid-sensing ion channel (ASIC) 1a.},
  author={Xuanmao Chen and Stefan Gr{\"u}nder},
  journal={The Journal of physiology},
  year={2007},
  volume={579 Pt 3},
  pages={657-70}
}
The homomeric acid-sensing ion channel 1a (ASIC1a) is a H+-activated ion channel with important physiological functions and pathophysiological impact in the central nervous system. Here we show that homomeric ASIC1a is distinguished from other ASICs by a reduced response to successive acid stimulations. Such a reduced response is called tachyphylaxis. We show that tachyphylaxis depends on H+ permeating through ASIC1a, that tachyphylaxis is attenuated by extracellular Ca2+, and that… CONTINUE READING