Permeance of Cs+ and Rb+ through the inwardly rectifying K+ channel in guinea pig ventricular myocytes

@article{Mitra1991PermeanceOC,
  title={Permeance of Cs+ and Rb+ through the inwardly rectifying K+ channel in guinea pig ventricular myocytes},
  author={Raman L. Mitra and Martin Morad},
  journal={The Journal of Membrane Biology},
  year={1991},
  volume={122},
  pages={33-42}
}
Inward currents carried by external Cs, Rb, NH4 and K through theI K1 channel were studied using a whole-cell voltage clamp technique. Cs, NH4, and Rb currents could be recorded negative to −40 mV following depolarizing prepulses (≥0 mV and 200–1000 msec in duration). The current activation displayed an instantaneous component followed by a monoexponential increase (τα) to a peak amplitude. Subsequent inactivation was fit by a single exponential, τiα. With hyperpolarization, τα and τi… CONTINUE READING

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