Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases.

@article{Kayed2004PermeabilizationOL,
  title={Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases.},
  author={Rakez Kayed and Yuri V Sokolov and Brian W Edmonds and Theresa M. McIntire and Saskia Charlotte Florence Milton and James Edwin Hall and Charles G. Glabe},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 45},
  pages={
          46363-6
        }
}
Amyloid fibrillization is multistep process involving soluble oligomeric intermediates, including spherical oligomers and protofibrils. Amyloid oligomers have a common, generic structure, and they are intrinsically toxic to cells, even when formed from non-disease related proteins, which implies they also share a common mechanism of pathogenesis and toxicity. Here we report that soluble oligomers from several types of amyloids specifically increase lipid bilayer conductance regardless of the… CONTINUE READING
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