Permeability properties of a three-cell type in vitro model of blood-brain barrier.

  title={Permeability properties of a three-cell type in vitro model of blood-brain barrier.},
  author={Gabriella Schiera and Sandra Sala and Alessia Gallo and Maria Pia Raffa and Giovanna Pitarresi and Giovanni Savettieri and Italia Di Liegro},
  journal={Journal of cellular and molecular medicine},
  volume={9 2},
We previously found that RBE4.B brain capillary endothelial cells (BCECs) form a layer with blood-brain barrier (BBB) properties if co-cultured with neurons for at least one week. As astrocytes are known to modulate BBB functions, we further set a culture system that included RBE4.B BCECs, neurons and astrocytes. In order to test formation of BBB, we measured the amount of 3H-sucrose able to cross the BCEC layer in this three-cell type model of BBB. Herein we report that both neurons and… CONTINUE READING

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