Permeability of the mammary gland to large antibiotic molecules.

@article{Ziv1973PermeabilityOT,
  title={Permeability of the mammary gland to large antibiotic molecules.},
  author={G. Ziv and F. Sulman},
  journal={Zentralblatt fur Veterinarmedizin. Reihe A},
  year={1973},
  volume={20 5},
  pages={
          388-94
        }
}
  • G. Ziv, F. Sulman
  • Published 1973
  • Chemistry, Medicine
  • Zentralblatt fur Veterinarmedizin. Reihe A
  • Summary The permeability of the blood-milk barrier to systemically administered spiramycin (m. w. 920), polymyxin B (m. w. 1,220), vancomycin (m. w. 3,200) and ristocetin (m. w. 5,000) was examined in lactating cows and ewes. Spiramycin penetrated into milk in accordance with the pH-pK non-ionic diffusion principle. Limited penetration of polymyxin B and vancomycin was observed while ristocetin was not detected in milk in spite of serum drug levels in excess of 10.0 mcg./ml… CONTINUE READING
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