Permeability of the blood-brain barrier to soluble cytokine receptors.

  title={Permeability of the blood-brain barrier to soluble cytokine receptors.},
  author={W. A. Banks and Scott Randall Plotkin and Abba J. Kastin},
  volume={2 3},
Soluble receptors for cytokines can be important regulators of cytokine function. By binding to their cytokine ligands, they act as antagonists and carrier proteins. We investigated whether the blood-to-brain saturable transport of human tumor necrosis factor-alpha (TNF) and human interleukin-1 alpha (IL-1) radioactively labeled with 125I could be blocked by preincubation with their soluble receptors. At ratios of 100:1 and 1,000:1 of receptor to cytokine, the soluble p75 human receptor to TNF… CONTINUE READING
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