Permeability of blood-brain barrier to various sized molecules.

  title={Permeability of blood-brain barrier to various sized molecules.},
  author={William G Mayhan and Donald D. Heistad},
  journal={The American journal of physiology},
  volume={248 5 Pt 2},
We studied disruption of the blood-brain barrier (BBB) by acute hypertension and a hyperosmolar solution. The goals were to determine whether 1) disruption of the BBB occurs primarily in arteries, capillaries, or veins, and 2) transport of different-sized molecules is homogeneous or size dependent. Sprague-Dawley rats were studied using intravital… CONTINUE READING