Permeability of blood-brain barrier in macaque model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson disease.

@article{Thiollier2016PermeabilityOB,
  title={Permeability of blood-brain barrier in macaque model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson disease.},
  author={Thibaud Thiollier and Caisheng Wu and Hugues Contamin and Qin Li and Jinlan Zhang and Erwan B{\'e}zard},
  journal={Synapse},
  year={2016},
  volume={70 6},
  pages={231-9}
}
Brain bioavailability of drugs developed to address central nervous system diseases is classically documented through cerebrospinal fluid collected in normal animals, i.e., through an approximation as there are fundamental differences between cerebrospinal fluid and tissue contents. The fact that disease might affect brain availability of drugs is almost never considered at this stage although several conditions are associated with blood-brain barrier damage. Building upon our expertise in… CONTINUE READING