Permeability of Rickettsia prowazekii to NAD.

  title={Permeability of Rickettsia prowazekii to NAD.},
  author={Will Atkinson and Herbert H. Winkler},
  journal={Journal of bacteriology},
  volume={171 2},
Rickettsia prowazekii accumulated radioactivity from [adenine-2,8-3H]NAD but not from [nicotinamide-4-3H]NAD, which demonstrated that NAD was not taken up intact. Extracellular NAD was hydrolyzed by rickettsiae with the products of hydrolysis, nicotinamide mononucleotide and AMP, appearing in the incubation medium in a time- and temperature-dependent manner. The particulate (membrane) fraction contained 90% of this NAD pyrophosphatase activity. Rickettsiae which had accumulated radiolabel after… CONTINUE READING


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