Permeability of PEGylated Immunoarsonoliposomes Through In Vitro Blood Brain Barrier-Medulloblastoma Co-culture Models for Brain Tumor Therapy

@article{AlShehri2014PermeabilityOP,
  title={Permeability of PEGylated Immunoarsonoliposomes Through In Vitro Blood Brain Barrier-Medulloblastoma Co-culture Models for Brain Tumor Therapy},
  author={Abdulghani Al-Shehri and Marco Emanuele Favretto and Panayiotis V. Ioannou and Ignacio Andres Romero and P Olivier Couraud and Babette Weksler and Terry L. Parker and Paraskevi Kallinteri},
  journal={Pharmaceutical Research},
  year={2014},
  volume={32},
  pages={1072-1083}
}
Owing to restricted access of pharmacological agents into the brain due to blood brain barrier (BBB) there is a need: 1. to develop a more representative 3-D-co-culture model of tumor-BBB interaction to investigate drug and nanoparticle transport into the brain for diagnostic and therapeutic evaluation. 2. to address the lack of new alternative methods to animal testing according to replacement-reduction-refinement principles. In this work, in vitro BBB-medulloblastoma 3-D-co-culture models… CONTINUE READING

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