Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia‐susceptible individuals

@article{Chang2019PermeabilisedSM,
  title={Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia‐susceptible individuals},
  author={L. Chang and C. Daly and D. Miller and P. Allen and J. Boyle and P. Hopkins and M. Shaw},
  journal={BJA: British Journal of Anaesthesia},
  year={2019},
  volume={122},
  pages={613–621}
}
Background: Individuals genetically susceptible to malignant hyperthermia (MH) exhibit hypermetabolic reactions when exposed to volatile anaesthetics. Mitochondrial dysfunction has previously been associated with the MH‐susceptible (MHS) phenotype in animal models, but evidence of this in human MH is limited. Methods: We used high resolution respirometry to compare oxygen consumption rates (oxygen flux) between permeabilised human MHS and MH‐negative (MHN) skeletal muscle fibres with or without… Expand
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