Permanent neonatal diabetes due to activating mutations in ABCC8 and KCNJ11

Abstract

The ATP-sensitive potassium (KATP) channel is composed of two subunits SUR1 and Kir6.2. The channel is key for glucose stimulated insulin release from the pancreatic beta cell. Activating mutations have been identified in the genes encoding these subunits, ABCC8 and KCNJ11, and account for approximately 40% of permanent neonatal diabetes cases. The majority… (More)
DOI: 10.1007/s11154-010-9149-x

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@article{Edghill2010PermanentND, title={Permanent neonatal diabetes due to activating mutations in ABCC8 and KCNJ11}, author={Emma L. Edghill and Sarah E. Flanagan and Sian Ellard}, journal={Reviews in Endocrine and Metabolic Disorders}, year={2010}, volume={11}, pages={193-198} }