Permanent hepatic artery ligation versus temporary dearterialization in the treatment of hepatic tumors.

  title={Permanent hepatic artery ligation versus temporary dearterialization in the treatment of hepatic tumors.},
  author={Stig Bengmark and Bengt W. Jeppsson},
  journal={Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer},
  • S. BengmarkB. Jeppsson
  • Published 1986
  • Medicine
  • Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
The rationale for treating liver tumors by occlusion therapy is based on the derivation of the nutrition of liver tumors from the hepatic artery. Vascularity of malignant neoplasms in the liver has been investigated by many authors. Breedis and Young [10] studied the tumor circulation of experimental liver neoplasms and autopsy specimens of patients, using various dyes, gelatin, and vinyl acetate for injections into hepatic arteries and veins. Dye was demonstrated within the tumors after… 
4 Citations

Liver Infusion Chemotherapy

The choice and the potential of the therapies currently available, particularly of systemic cytostatic therapy for primary liver tumors and for most hepatic metastases, is extremely limited and new treatment modalities are thus being sought.

Liver-Directed Therapies for Colorectal Metastases

The rationale and technique of various modalities that are used to try to eradicate or control these lesions through locally-directed therapy are addressed.



Hepatic artery ligation and tumor necrosis in the liver.

The purpose of this report is to describe the case and draw conclusions as to the special character of the blood supply to metastatic tumor tissue in the liver.

Ligation and catheterization of the hepatic artery for palliative treatment of malignant hepatic tumors

Eleven unresectable hepatoma patients and three metastatic tumor patients with colonic cancer underwent ligation and/or catheterization of the hepatic artery of the main tumor‐bearing zone and Mitomycin C or Adriamycin was administered via the catheter intermittently or continuously with a portable pump device.

Evaluation of the ligation of the hepatic artery and regional arterial chemotherapy in the treatment of primary and secondary cancer of the liver.

The most promising result in the treatment of hepatic malignancies was achieved by liver resection two to four months after the initial ligation of the hepatic artery, whereas from the authors' experiences the final value of regional arterial chemotherapy is still unsettled.

Transient hepatic dearterialization followed by regional intra-arterial 5-fluorouracil infusion as treatment for liver tumors.

Twenty consecutive patients with secondary liver tumors were treated with a new method of liver dearterialization, performed by transient occlusion of the hepatic artery with strangulating slings, and followed by regional intra-arterial infusion of 5-fluorouracil, finding it suitable for patients with a tumor of moderate severity involving both liver lobes and without extrahepatic tumor growth.

Hepatic artery ligation and cytotoxic infusion in treatment of liver metastases.

Since 1970, 38 patients with multiple primary or secondary liver neoplasms have been treated by hepatic artery ligation and distal cytotoxic infusion with fluorouracil with minimal morbidity and mortality.

Tumor vascularity as a prognostic factor for hepatic tumors.

The results indicate that the more vascular the hepatic tumor on angiogram, the better the prognosis following hepatic artery ligation and infusional chemotherapy.

Hepatic artery ligation for liver metastasis in colorectal carcinoma

Results reveal that factors that adversely affect survival for hepatic artery ligation are extrahepatic metastasis, poor performance status, and elevated liver function tests (alkaline phosphatase 2 times normal).