Permanent growth arrest in irradiated human fibroblasts.

  title={Permanent growth arrest in irradiated human fibroblasts.},
  author={Jason G Savell and Sharmila Rao and Warren Jack Pledger and Walker Wharton},
  journal={Radiation research},
  volume={155 4},
Exposure of human fibroblasts to doses of ionizing radiation sufficient to cause a permanent growth arrest repressed the expression of genes induced late during G(0)/G(1)-phase traverse, including both cyclin A and cyclin E. In addition, radiation prevented the cell cycle-dependent activation of cyclin D1-associated kinase activity and the subsequent phosphorylation of the RB tumor suppressor protein. Exposure to radiation did not alter the cellular levels of cyclin D1 protein, nor did it alter… CONTINUE READING