Permanent focal and transient global cerebral ischemia increase glial and neuronal expression of heme oxygenase-1, but not heme oxygenase-2, protein in rat brain

@article{Geddes1996PermanentFA,
  title={Permanent focal and transient global cerebral ischemia increase glial and neuronal expression of heme oxygenase-1, but not heme oxygenase-2, protein in rat brain},
  author={James W. Geddes and Luther Creed Pettigrew and Mary L. Holtz and Susan D. Craddock and Mahin D. Maines},
  journal={Neuroscience Letters},
  year={1996},
  volume={210},
  pages={205-208}
}
Two heme oxygenase (HO) proteins have been identified to date; HO-1, a stress-induced protein, and HO-2, a constitutively expressed isoform. Recently, it was demonstrated that HO-1 mRNA expression is increased following transient global ischemia. The present study examined the effects of global and focal ischemia on HO-1 and HO-2 protein, using immunocytochemistry. Following 20 min of ischemia (rat 4 vessel occlusion model with hypotension) and 6 h of recirculation, increased HO-1… CONTINUE READING
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