Permanent distal occlusion of middle cerebral artery in rat causes local increased ETB, 5-HT₁B and AT₁ receptor-mediated contractility downstream of occlusion.

@article{Rasmussen2013PermanentDO,
  title={Permanent distal occlusion of middle cerebral artery in rat causes local increased ETB, 5-HT₁B and AT₁ receptor-mediated contractility downstream of occlusion.},
  author={Marianne Nelly Paola Rasmussen and Malene Hornbak and Stine Schmidt Larsen and Majid Sheykhzade and Lars Edvinsson},
  journal={Journal of vascular research},
  year={2013},
  volume={50 5},
  pages={396-409}
}
BACKGROUND/AIMS In response to experimental stroke, a characteristic functional and expressional upregulation of contractile G-protein-coupled receptors has been uncovered in the affected cerebral vasculature; however, the mechanism initiating this phenomenon remains unknown. METHODS Using a model of permanent distal occlusion of rat middle cerebral arteries, we investigated whether there was a regional difference in receptor-mediated contractility of segments located upstream and downstream… CONTINUE READING