Permanent Genetic Access to Transiently Active Neurons via TRAP: Targeted Recombination in Active Populations

@article{Guenthner2013PermanentGA,
  title={Permanent Genetic Access to Transiently Active Neurons via TRAP: Targeted Recombination in Active Populations},
  author={Casey J. Guenthner and Kazunari Miyamichi and Helen H Yang and H. Craig Heller and Liqun Luo},
  journal={Neuron},
  year={2013},
  volume={79}
}
Targeting genetically encoded tools for neural circuit dissection to relevant cellular populations is a major challenge in neurobiology. We developed an approach, targeted recombination in active populations (TRAP), to obtain genetic access to neurons that were activated by defined stimuli. This method utilizes mice in which the tamoxifen-dependent recombinase CreER(T2) is expressed in an activity-dependent manner from the loci of the immediate early genes Arc and Fos. Active cells that express… CONTINUE READING
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