Permanent CD8+ T Cell Depletion Prevents Proteinuria in Active Heymann Nephritis

@article{Penny1998PermanentCT,
  title={Permanent CD8+ T Cell Depletion Prevents Proteinuria in Active Heymann Nephritis },
  author={Mark J. Penny and Rochelle A. Boyd and Bruce Milne Hall},
  journal={The Journal of Experimental Medicine},
  year={1998},
  volume={188},
  pages={1775 - 1784}
}
Active Heymann nephritis (HN) is a rat model of human idiopathic membranous nephropathy in which injury is thought to be mediated by membrane attack complex of complement (MAC) activated by antibody (Ab) to glomerular epithelial cells. Recent work has shown that HN develops in C6-deficient rats which cannot assemble MAC, and that infiltration of activated cytotoxic CD8(+) T cells and macrophages into glomeruli coincides with proteinuria. This study examined the role of CD8(+) T cells in… CONTINUE READING

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