Perlecan and the Blood-Brain Barrier: Beneficial Proteolysis?

  title={Perlecan and the Blood-Brain Barrier: Beneficial Proteolysis?},
  author={Jill Roberts and Michael P. Kahle and Gregory J Bix},
  booktitle={Front. Pharmacol.},
The cerebral microvasculature is important for maintaining brain homeostasis. This is achieved via the blood-brain barrier (BBB), composed of endothelial cells with specialized tight junctions, astrocytes, and a basement membrane (BM). Prominent components of the BM extracellular matrix (ECM) include fibronectin, laminin, collagen IV, and perlecan, all of which regulate cellular processes via signal transduction through various cell membrane bound ECM receptors. Expression and proteolysis of… CONTINUE READING
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