Perlecan: how does one molecule do so many things?

  title={Perlecan: how does one molecule do so many things?},
  author={Sarah S Knox and John M Whitelock},
  journal={Cellular and Molecular Life Sciences CMLS},
Perlecan is a large multi-domain extracellular matrix proteoglycan that plays a crucial role in tissue development and organogenesis. In vertebrates, perlecan functions in a diverse range of developmental and biological processes, from the establishment of cartilage to the regulation of wound healing. How can a single molecule modulate such a wide variety of processes? We suggest that perlecan employs the same basic mechanism, based on interactions with growth factors, morphogens and matrix… CONTINUE READING
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