Perlecan: how does one molecule do so many things?

@article{Knox2006PerlecanHD,
  title={Perlecan: how does one molecule do so many things?},
  author={Sarah S Knox and John M Whitelock},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2006},
  volume={63},
  pages={2435-2445}
}
Perlecan is a large multi-domain extracellular matrix proteoglycan that plays a crucial role in tissue development and organogenesis. In vertebrates, perlecan functions in a diverse range of developmental and biological processes, from the establishment of cartilage to the regulation of wound healing. How can a single molecule modulate such a wide variety of processes? We suggest that perlecan employs the same basic mechanism, based on interactions with growth factors, morphogens and matrix… CONTINUE READING
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Ribozyme - mediated perlecan knockdown impairs chondrogenic differentiation of C 3 H 10 T 1 / 2 fibroblasts

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