Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo.

@article{Hickey1988PerivascularMC,
  title={Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo.},
  author={William F. Hickey and Hiroshi Kimura},
  journal={Science},
  year={1988},
  volume={239 4837},
  pages={290-2}
}
A crucial question in the study of immunological reactions in the central nervous system (CNS) concerns the identity of the parenchymal cells that function as the antigen-presenting cells in that organ. Rat bone marrow chimeras and encephalitogenic, major histocompatability--restricted T-helper lymphocytes were used to show that a subset of endogenous CNS cells, commonly termed "perivascular microglial cells," is bone marrow-derived. In addition, these perivascular cells are fully competent to… CONTINUE READING
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