Perivascular inflammatory cells in ovine Visna/maedi encephalitis and their possible role in virus infection and lesion progression

@article{Polledo2012PerivascularIC,
  title={Perivascular inflammatory cells in ovine Visna/maedi encephalitis and their possible role in virus infection and lesion progression},
  author={Laura Polledo and Jorge Gonz{\'a}lez and Julio Benavides and Beatriz Mart{\'i}nez-Fern{\'a}ndez and Ma. Carmen Ferreras and Juan Francisco Garc{\'i}a Mar{\'i}n},
  journal={Journal of NeuroVirology},
  year={2012},
  volume={18},
  pages={532-537}
}
We examined the distribution in the perivascular spaces of Visna/maedi antigen, T cells (CD3+, CD4+ and CD8+), B cells and macrophages by immunohistochemistry in 22 natural cases of Visna/maedi encephalitis. Sheep showed lymphocytic or histiocytic lesions. In mild lymphocytic lesions, the viral antigen was detected in perivascular cuffs where CD8+ T cells… CONTINUE READING