Perivascular fatty tissue at the brachial artery is linked to insulin resistance but not to local endothelial dysfunction

@article{Rittig2008PerivascularFT,
  title={Perivascular fatty tissue at the brachial artery is linked to insulin resistance but not to local endothelial dysfunction},
  author={Kilian Rittig and K. Staib and J{\"u}rgen Machann and Michael Boettcher and Andreas Peter and Fritz Schick and Claus D. Claussen and Norbert Stefan and Andreas Fritsche and H. U. H{\"a}ring and Bernd M. Balletshofer},
  journal={Diabetologia},
  year={2008},
  volume={51},
  pages={2093-2099}
}
Different ectopic fat depots, such as visceral or hepatic fat, are known to affect whole body insulin sensitivity. It has recently been hypothesised that differences in perivascular adipose tissue (PVAT) mass around resistance vessels may also contribute to insulin resistance, possibly via direct vascular effects leading to reduced capillary cross-sectional area in the muscle, which in turn affects muscular blood flow and glucose uptake. Based on this, the aim of the present study was to test… CONTINUE READING

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