Perivascular fat-mediated vascular dysfunction and remodeling through the AMPK/mTOR pathway in high-fat diet-induced obese rats

@article{Ma2010PerivascularFV,
  title={Perivascular fat-mediated vascular dysfunction and remodeling through the AMPK/mTOR pathway in high-fat diet-induced obese rats},
  author={Liqun Ma and Shuangtao Ma and Hongbo He and Dachun Yang and Xiaoping Chen and Zhidan Luo and Daoyan Liu and Zhiming Zhu},
  journal={Hypertension Research},
  year={2010},
  volume={33},
  pages={446-453}
}
Perivascular adipose tissue (PVAT) is implicated in the regulation of vascular function in the physiological state, but the modulatory effect of PVAT on vasculature during obesity is poorly understood. Endothelial nitric oxide synthase (eNOS), AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) participate in the regulation of vascular function. We therefore investigated whether PVAT has a potential role through the AMPK/mTOR pathway in obesity-related vascular… CONTINUE READING
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