Peritumoral SPARC expression and patient outcome with resectable intrahepatic cholangiocarcinoma

Abstract

BACKGROUND AND OBJECTIVES Cholangiocarcinoma (CCA) affects thousands worldwide with increasing incidence. SPARC (secreted protein acidic and rich in cysteine) plays an important role in cellular matrix interactions, wound repair, and cellular migration, and has been reported to prevent malignancy from growth. SPARC undergoes epigenetic silencing in… (More)
DOI: 10.2147/OTT.S78728

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