Peritoneal dialysis with solutions containing amino acids plus glucose promotes protein synthesis during oral feeding.

@article{Tjiong2007PeritonealDW,
  title={Peritoneal dialysis with solutions containing amino acids plus glucose promotes protein synthesis during oral feeding.},
  author={Hoey Lan Tjiong and Trinet Rietveld and Josias L Wattimena and J Willem O van den Berg and Devada Kahriman and J O M van der Steen and Wim C. J. Hop and Roel Swart and Marien W.J.A. Fieren},
  journal={Clinical journal of the American Society of Nephrology : CJASN},
  year={2007},
  volume={2 1},
  pages={
          74-80
        }
}
Inadequate food intake plays an important role in the development of malnutrition. [...] Key Method A crossover study was performed in 12 CAPD patients to compare, at 7-d intervals, a mixture of AA (Nutrineal 1.1%) plus G (Physioneal l.36 to 3.86%) versus G only as control dialysate. Whole-body protein turnover was studied by primed constant intravenous infusion of (13)C-leucine during the 9-h dialysis.Expand
Dialysate as food as an option for automated peritoneal dialysis
Protein-energy malnutrition is frequently found in dialysis patients. Many factors play a role in its development including deficient nutrient intake as a result of anorexia. Peritoneal dialysis (PD)Expand
Albumin and whole-body protein synthesis respond differently to intraperitoneal and oral amino acids.
TLDR
The findings show that the supply of AAs has different effects on whole-body protein synthesis and the fractional synthetic rate of albumin. Expand
Amino Acid-Based Peritoneal Dialysis Solutions for Malnutrition: New Perspectives
TLDR
It is advocated consideration of usage of AA/glucose dialysate when PD patients cannot comply with dietary requirements and to evaluate the long-term effects of this approach on morbidity and mortality, clinical trials with large groups of patients are needed. Expand
Peritoneal Protein Losses and Cytokine Generation in Automated Peritoneal Dialysis with Combined Amino Acids and Glucose Solutions
TLDR
Nightly APD with amino acids containing dialysate was associated with an increase in peritoneal IL-6 generation during the day and the addition of AA to standard glucose dialysis solutions did not induce a significant increase of peritoneAL protein losses. Expand
Comparison of Intraperitoneal Amino Acid and Oral Amino Acid Supplements in Peritoneal Dialysis Patients
TLDR
Although treatment with AAs supplements administered either intraperitoneally or orally, can be considered a good nutritional support, it should be borne in mind that the important point is to increase the amount of dietary protein intake in individual patients. Expand
Bioactive rather than total IGF-I is involved in acute responses to nutritional interventions in CAPD patients.
  • M. Brugts, H. L. Tjiong, +4 authors J. Janssen
  • Medicine
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2010
TLDR
Investigating in CAPD patients whether circulating insulin-like growth factor-I (IGF-I) bioactivity may offer a more sensitive index to acute nutritional interventions than total IGF-I found evidence that inCAPD patients changes in circulating IGF- I bioactivity are associated with nutrient intake and that IGF-i bioactivity rather than total insulin-I is involved in acute responses to nutritional interventions in CAPd patients. Expand
Bicarbonate-Based Peritoneal Dialysis Solution has Less Effect on Ingestive Behavior than Lactate-Based Peritoneal Dialysis Solution
TLDR
The results show possible benefit on appetite of reducing the lactate concentration in PD solutions, which was due partially to the use of bicarbonate. Expand
Whole-body protein turnover in peritoneal dialysis patients: a comparison of the [15N]glycine end product and the [13C]leucine precursor methods.
TLDR
While the precursor method shows less variation, the more convenient end-product method may be useful in larger groups of selected patients including those on PD. Expand
Commencing peritoneal dialysis with 1.1% amino acid solution does not influence biochemical nutritional parameters in incident CAPD patients
TLDR
Amo acid solutions conferred no demonstrable benefit on biochemical parameters in incident CAPD patients and the effects of AAS may be different when added to the CAPD regimen of patients undergoing prior CAPD treatment. Expand
Peritoneal dialysis solution and nutrition.
  • C. Verger
  • Medicine
  • Contributions to nephrology
  • 2012
TLDR
There is not actually a single universal solution to minimize malnutrition in peritoneal dialysis patients, and various combinations of solutions adapted to different patient profiles are required. Expand
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References

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Effects of an amino acid dialysate on leucine metabolism in continuous ambulatory peritoneal dialysis patients.
TLDR
This amino acids solution is efficaciously utilized for protein synthesis in CAPD patients with no effect on protein breakdown, and the concomitant ingestion of a carbohydrate-lipid meal inhibits protein breakdown and reinforces a positive effect of the amino acid solution on protein balance. Expand
Dialysate as food: combined amino acid and glucose dialysate improves protein anabolism in renal failure patients on automated peritoneal dialysis.
TLDR
In conclusion, APD with AA plus G dialysate improves protein kinetics and this dialysis procedure may improve the nutritional status in malnourished PD patients. Expand
Acute effects of simultaneous intraperitoneal infusion of glucose and amino acids.
TLDR
This peritoneal dialysis procedure may improve utilization of AA for protein synthesis, as suggested by the lack of increase of the BUN levels with this regimen. Expand
Metabolic balance studies and dietary protein requirements in patients undergoing continuous ambulatory peritoneal dialysis.
TLDR
The relation between protein intake and nitrogen balance suggests that the daily protein requirement for clinically stable CAPD patients should be at least 1.1 g/kg/day; to account for variability among subjects 1.2 to 1.3 g protein/kg-day is probably preferable. Expand
Acute effects of peritoneal dialysis with dialysates containing dextrose or dextrose and amino acids on muscle protein turnover in patients with chronic renal failure.
TLDR
This study indicates that in PD patients in the fasting state, the moderate hyperinsulinemia that occurs during PD with dextrose alone causes an antiproteolytic action that is obscured by a parallel decrease in AA availability for PS. Expand
Replacement of Amino Acid and Protein Losses with 1.1% Amino Acid Peritoneal Dialysis Solution
TLDR
Daily losses of AAs and proteins into dialysate are more than offset by gains of A as absorbed from one exchange with 1.1% AA-based dialysis solution, and the difference was relatively constant across a wide range of membrane transport types. Expand
Protein intake during hemodialysis maintains a positive whole body protein balance in chronic hemodialysis patients.
TLDR
It is concluded that the consumption of a protein- and energy-enriched meal by CHD patients while dialyzing can strongly improve whole body protein balance, probably because of the increased amino acid concentrations in blood. Expand
Treatment of malnutrition with 1.1% amino acid peritoneal dialysis solution: results of a multicenter outpatient study.
  • M. Jones, T. Hagen, +21 authors J. Moran
  • Medicine
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  • 1998
TLDR
Treatment with one or two exchanges daily of this amino acid-based PD solution is safe and provides nutritional benefit for malnourished PD patients, and changes from baseline did not differ between groups. Expand
CAPD with an amino acid dialysis solution: a long-term, cross-over study.
TLDR
It is concluded that amino acids can be used as osmotic agents for CAPD since they do not cause toxic effects or impair peritoneal membrane function and they can help the nutritional status, provided that an increase in weight is prevented and the slight worsening of systemic acidosis is corrected. Expand
Adaptation to low-protein diets in renal failure: leucine turnover and nitrogen balance.
TLDR
Patients with CRF can activate appropriate adaptive responses to LP inasmuch as reduced amino acid oxidation occurring with feeding and estimates of protein balance did not differ from control. Expand
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