Perisynaptic organization of plasma membrane calcium pumps in cerebellar cortex.

@article{Burette2007PerisynapticOO,
  title={Perisynaptic organization of plasma membrane calcium pumps in cerebellar cortex.},
  author={Alain C. Burette and Richard J. Weinberg},
  journal={The Journal of comparative neurology},
  year={2007},
  volume={500 6},
  pages={1127-35}
}
Calcium, a ubiquitous intracellular messenger, regulates numerous intracellular signaling pathways. To permit specificity of signal transduction and prevent unwanted cross-talk between pathways, sites of calcium entry in neurons are localized to specific membrane domains. To test whether Ca(2+) extrusion pumps might exhibit analogous compartmentalization, we used immunohistochemistry to determine the subcellular localization of the two main plasma membrane Ca(2+)-ATPase (PMCA) isoforms in the… CONTINUE READING
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