Perisurgical amitriptyline produces a preventive effect on afferent hypersensitivity following spared nerve injury.

@article{Arsenault2009PerisurgicalAP,
  title={Perisurgical amitriptyline produces a preventive effect on afferent hypersensitivity following spared nerve injury.},
  author={Andr{\'e} Arsenault and Jana Sawynok},
  journal={Pain},
  year={2009},
  volume={146 3},
  pages={308-14}
}
Following surgery, nerve injury can lead to persistent neuropathic pain. Pre-emptive and preventive analgesic treatments in the perioperative period aim to minimize nerve injury-induced pain. Here we demonstrate that a perioperative regimen of amitriptyline (10 mg/kg i.p. 30 min before and immediately after surgery, followed by oral amitriptyline 15-18 mg/kg/day in the drinking water for 7 days post-surgery) prevents hypersensitivity to a chemogenic stimulus (alphabeta-MeATP, a ligand for P2X3… CONTINUE READING