Perispinal etanercept for neuroinflammatory disorders.

  title={Perispinal etanercept for neuroinflammatory disorders.},
  author={Edward Lewis Tobinick},
  journal={Drug discovery today},
  volume={14 3-4},
Excess TNF is centrally involved in the pathogenesis of a variety of neuroinflammatory disorders, including Alzheimer's disease, other forms of dementia, intervertebral disc-related pain, and related disorders. TNF causes neuronal dysfunction, regulates synaptic mechanisms, and mediates amyloid-induced disruption of molecular mechanisms involved in memory. Perispinal administration of etanercept, a potent anti-TNF fusion protein, is a treatment modality whose rapid clinical effects may be… CONTINUE READING