Peripubertal vitamin D(3) deficiency delays puberty and disrupts the estrous cycle in adult female mice.

@article{Dicken2012PeripubertalVD,
  title={Peripubertal vitamin D(3) deficiency delays puberty and disrupts the estrous cycle in adult female mice.},
  author={Cary L Dicken and Davelene D Israel and Joe B Davis and Yan Sun and Jun Shu and John C Hardin and Genevieve S. Neal-Perry},
  journal={Biology of reproduction},
  year={2012},
  volume={87 2},
  pages={51}
}
The mechanism(s) by which vitamin D(3) regulates female reproduction is minimally understood. We tested the hypothesis that peripubertal vitamin D(3) deficiency disrupts hypothalamic-pituitary-ovarian physiology. To test this hypothesis, we used wild-type mice and Cyp27b1 (the rate-limiting enzyme in the synthesis of 1,25-dihydroxyvitamin D(3)) null mice to study the effect of vitamin D(3) deficiency on puberty and reproductive physiology. At the time of weaning, mice were randomized to a… CONTINUE READING