Peripubertal exposure to the neonicotinoid pesticide dinotefuran affects dopaminergic neurons and causes hyperactivity in male mice

  title={Peripubertal exposure to the neonicotinoid pesticide dinotefuran affects dopaminergic neurons and causes hyperactivity in male mice},
  author={Naoki Yoneda and Tadashi Takada and Tetsushi Hirano and Shogo Yanai and Anzu Yamamoto and Youhei Mantani and Toshifumi Yokoyama and Hiroshi Kitagawa and Yoshiaki Tabuchi and Nobuhiko Hoshi},
  journal={The Journal of Veterinary Medical Science},
  pages={634 - 637}
Although neonicotinoid pesticides are expected to have harmful influence on mammals, there is little animal experimental data to support the effect and mechanisms. Since acetylcholine causes the release of dopamine, neonicotinoids may confer a risk of developmental disorders via a disturbance in the monoamine systems. Male mice were peripubertally administered dinotefuran (DIN) referring to no observed effect level (NOEL) and performed behavioral and immunohistological analyses. In an open… 

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