Periprostatic adipose tissue as a modulator of prostate cancer aggressiveness.

  title={Periprostatic adipose tissue as a modulator of prostate cancer aggressiveness.},
  author={David S. Finley and Valerie S. Calvert and Junichi Inokuchi and Alice Lau and Navneet R Narula and Emanual F. Petricoin and Frank Zaldivar and Rosanne Santos and Darren R Tyson and David K. Ornstein},
  journal={The Journal of urology},
  volume={182 4},
PURPOSE Adipose tissue has been suggested to contribute to the pathogenesis of various disease states, including prostate cancer. We investigated the association of cytokines and growth factors secreted by periprostatic adipose tissue with pathological features of aggressive prostate cancer. MATERIALS AND METHODS Periprostatic adipose tissue was harvested from patients undergoing radical prostatectomy and cultured for 24 hours to generate conditioned medium or snap frozen immediately for… CONTINUE READING


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