Peripherin and neurofilament protein coexist in spinal spheroids of motor neuron disease.

@article{Corbo1992PeripherinAN,
  title={Peripherin and neurofilament protein coexist in spinal spheroids of motor neuron disease.},
  author={Massimo Corbo and Arthur P. Hays},
  journal={Journal of neuropathology and experimental neurology},
  year={1992},
  volume={51 5},
  pages={531-7}
}
We have compared the immunolocalization of neurofilament protein (NF) with two other neuronal-specific intermediate filament proteins in large spinal axonal swellings (spheroids) of motor neuron disease and controls. All spheroids labeled each of the three different subunits of NF, the low, middle, and high molecular weight polypeptides. In doublelabel immunofluorescence, 300 axonal swellings were immunostained for NF, and 87% of them contained the intermediate protein peripherin. The pattern… CONTINUE READING

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