Peripherally injected linalool and bergamot essential oil attenuate mechanical allodynia via inhibiting spinal ERK phosphorylation.

@article{Kuwahata2013PeripherallyIL,
  title={Peripherally injected linalool and bergamot essential oil attenuate mechanical allodynia via inhibiting spinal ERK phosphorylation.},
  author={Hikari Kuwahata and Takaaki Komatsu and Soh Katsuyama and Maria Tiziana Corasaniti and Giacinto Bagetta and Shinobu Sakurada and Tsukasa Sakurada and Kazuo Takahama},
  journal={Pharmacology, biochemistry, and behavior},
  year={2013},
  volume={103 4},
  pages={735-41}
}
Bergamot essential oil (BEO) is one of the most common essential oil containing linalool and linalyl acetate as major volatile components. This study investigated the effect of intraplantar (i.pl.) bergamot essential oil (BEO) or linalool on neuropathic hypersensitivity induced by partial sciatic nerve ligation (PSNL) in mice. The i.pl. injection of BEO or linalool into the ipsilateral hindpaw to PSNL reduced PSNL-induced mechanical allodynia in a dose-dependent manner. Peripheral (i.pl… CONTINUE READING
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