Peripherally injected cholecystokinin-induced neuronal activation is modified by dietary composition in mice

@article{Zeeni2010PeripherallyIC,
  title={Peripherally injected cholecystokinin-induced neuronal activation is modified by dietary composition in mice},
  author={N. Zeeni and Nachiket Nadkarni and Jimmy D. Bell and Patrick C Even and G. Fromentin and Daniel Tom{\'e} and N. Darcel},
  journal={NeuroImage},
  year={2010},
  volume={50},
  pages={1560-1565}
}
The aim of this study was to investigate the effect of long-term nutrient intake on the central response to the anorexigenic gut hormone CCK. C57BL/6 mice were fed one of three diets for 6 weeks: standard high carbohydrate (HC), high fat (HF), or high protein (HP). Assessment of brain response to cholecystokinin (CCK) by manganese-enhanced MRI (MEMRI) showed a reduction in neuronal activity both in an appetite-related area (ventromedial nucleus of the hypothalamus) and areas associated with… CONTINUE READING

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