Peripherally driven low-threshold inhibitory inputs to lamina I local-circuit and projection neurones: a new circuit for gating pain responses.

@article{Luz2014PeripherallyDL,
  title={Peripherally driven low-threshold inhibitory inputs to lamina I local-circuit and projection neurones: a new circuit for gating pain responses.},
  author={Liliana L. Luz and P{\'e}ter Cs{\'o}ka - D{\'a}niel Havran - N{\'o}ra Szűcs and Boris V. Safronov},
  journal={The Journal of physiology},
  year={2014},
  volume={592 7},
  pages={1519-34}
}
Spinal lamina I is a key element of the pain processing system which relays primary afferent input to supraspinal areas. However, little is known about how the signal is modulated by its intrinsic network including local-circuit neurones (LCNs) and much less numerous anterolateral tract projection neurones (PNs). Here, we used whole-cell patch clamp recordings in an isolated spinal cord preparation to examine properties of identified LCNs (n = 85) and PNs (n = 73) in their functionally… CONTINUE READING
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