Peripherally administered desacetyl alpha-MSH and alpha-MSH both influence postnatal rat growth and associated rat hypothalamic protein expression.

@article{Wu2006PeripherallyAD,
  title={Peripherally administered desacetyl alpha-MSH and alpha-MSH both influence postnatal rat growth and associated rat hypothalamic protein expression.},
  author={Chia-Shan Jenny Wu and David R Greenwood and Janine M Cooney and Dwayne J. Jensen and Michele A. Tatnell and Garth J S Cooper and Kathleen G. Mountjoy},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2006},
  volume={291 6},
  pages={
          E1372-80
        }
}
Desacetyl alpha-MSH predominates over alpha-MSH during development, but whether it is biologically active and has a physiological role is unclear. We compared the effects of 0.3 microg.g(-1).day(-1) desacetyl alpha-MSH with that of 0.3 microg.g(-1).day(-1) alpha-MSH on postnatal body growth by administering the peptides subcutaneously daily for postnatal days 0-14 and also used a two-dimensional gel electrophoresis gel-based proteomic approach to analyze protein changes in hypothalami, the… CONTINUE READING