Corpus ID: 9771885

Peripherally administered desacetyl alpha-MSH and alpha-MSH both influence postnatal rat growth and associated rat hypothalamic protein expression.

@article{Wu2006PeripherallyAD,
  title={Peripherally administered desacetyl alpha-MSH and alpha-MSH both influence postnatal rat growth and associated rat hypothalamic protein expression.},
  author={C. J. Wu and D. Greenwood and J. Cooney and D. Jensen and M. Tatnell and G. Cooper and K. Mountjoy},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2006},
  volume={291 6},
  pages={
          E1372-80
        }
}
Desacetyl alpha-MSH predominates over alpha-MSH during development, but whether it is biologically active and has a physiological role is unclear. We compared the effects of 0.3 microg.g(-1).day(-1) desacetyl alpha-MSH with that of 0.3 microg.g(-1).day(-1) alpha-MSH on postnatal body growth by administering the peptides subcutaneously daily for postnatal days 0-14 and also used a two-dimensional gel electrophoresis gel-based proteomic approach to analyze protein changes in hypothalami, the… Expand
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